RT Journal Article
SR Electronic
T1 Thalamic neuronal activity correlated with essential tremor
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 273
OP 276
DO 10.1136/jnnp.64.2.273
VO 64
IS 2
A1 S E Hua
A1 F A Lenz
A1 T A Zirh
A1 S G Reich
A1 P M Dougherty
YR 1998
UL http://jnnp.bmj.com/content/64/2/273.abstract
AB Animal studies suggest that an olivocerebello-bulbospinal pathway mediates harmaline induced tremor, which resembles essential tremor in humans. However, recent evidence suggests that thalamocortical pathways participate in essential tremor. Thalamic single neuron activity has been analysed during thalamotomy for essential tremor. It has been shown by spectral cross correlation analysis that thalamic activity has a significant, linear relation to forearm EMG activity during tremor. The presence of this tremor related activity at the site where a lesion abolishes essential tremor suggests that the thalamus has an important role in the mechanism of essential tremor.