RT Journal Article
SR Electronic
T1 Orbital high resolution magnetic resonance imaging with fast spin echo in the acute stage of Leber’s hereditary optic neuropathy
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 124
OP 127
DO 10.1136/jnnp.64.1.124
VO 64
IS 1
A1 Yukihiko Mashima
A1 Kazuhiro Oshitari
A1 Yutaka Imamura
A1 Suketaka Momoshima
A1 Hayao Shiga
A1 Yoshihisa Oguchi
YR 1998
UL http://jnnp.bmj.com/content/64/1/124.abstract
AB Some evidence suggests that the primary locus of the lesion in Leber’s hereditary optic neuropathy (LHON) may be intraocular rather than retrobulbar. To clarify this issue, the condition of the retrobulbar portion of the optic nerve was evaluated in patients with the acute stage of LHON. High resolution MRI with fast spin echo sequences of the optic nerve complex in the orbit was carried out. Five patients with acute stage LHON were compared with seven patients with acute stage optic neuritis. On T2 weighted fast spin echo MRI, signal changes did not appear in the retrobulbar optic nerve complex in acute stage LHON. By comparison, patients with optic neuritis showed pronounced high signals in the optic nerve. Subsequent orbital MRI in the atrophic stages of the same patients with LHON showed an increase in signal intensity in the optic nerve toward the orbital apex in both eyes. The present results support the hypothesis that a primary lesion in LHON may be intraocular.