PT  - JOURNAL ARTICLE
AU  - Rudolf A Kristof
AU  - Hans Clusmann
AU  - Walter Koehler
AU  - Klaus B Fink
AU  - Johannes Schramm
TI  - Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange
AID  - 10.1136/jnnp.64.3.379
DP  - 1998 Mar 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 379--381
VI  - 64
IP  - 3
4099  - http://jnnp.bmj.com/content/64/3/379.short
4100  - http://jnnp.bmj.com/content/64/3/379.full
SO  - J Neurol Neurosurg Psychiatry1998 Mar 01; 64
AB  - An accidental high dose of intraventricular mezlocillin was given during antibiotic treatment for pneumonia in a patient admitted because of severe traumatic brain injury and occlusive hydrocephalus. Because of serial epileptic seizures not responsive to antiepileptic drug treatment, CSF exchange was performed. The CSF was drained through a ventricular catheter, while mock CSF was infused into the lumbar subarachnoid space. The patient soon recovered to her clinical status previous to intraventricular mezlocillin application. Side effects of CSF exchange were not seen. Under continued antiepileptic medication no more seizures occurred. It is concluded that high doses of intraventricular mezlocillin have proconvulsive effects. In this patient CSF exchange was a suitable means of preventing putatively permanent impairment of brain function caused by serial epileptic seizures due to intraventricular mezlocillin application.