RT Journal Article
SR Electronic
T1 Treatment of accidental high dose intraventricular mezlocillin application by cerebrospinal fluid exchange
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 379
OP 381
DO 10.1136/jnnp.64.3.379
VO 64
IS 3
A1 Rudolf A Kristof
A1 Hans Clusmann
A1 Walter Koehler
A1 Klaus B Fink
A1 Johannes Schramm
YR 1998
UL http://jnnp.bmj.com/content/64/3/379.abstract
AB An accidental high dose of intraventricular mezlocillin was given during antibiotic treatment for pneumonia in a patient admitted because of severe traumatic brain injury and occlusive hydrocephalus. Because of serial epileptic seizures not responsive to antiepileptic drug treatment, CSF exchange was performed. The CSF was drained through a ventricular catheter, while mock CSF was infused into the lumbar subarachnoid space. The patient soon recovered to her clinical status previous to intraventricular mezlocillin application. Side effects of CSF exchange were not seen. Under continued antiepileptic medication no more seizures occurred. It is concluded that high doses of intraventricular mezlocillin have proconvulsive effects. In this patient CSF exchange was a suitable means of preventing putatively permanent impairment of brain function caused by serial epileptic seizures due to intraventricular mezlocillin application.