RT Journal Article
SR Electronic
T1 Functional organisation of saccades and antisaccades in the frontal lobe in humans: a study with echo planar functional magnetic resonance imaging
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 374
OP 377
DO 10.1136/jnnp.65.3.374
VO 65
IS 3
A1 R M Müri
A1 O Heid
A1 A C Nirkko
A1 C Ozdoba
A1 J Felblinger
A1 G Schroth
A1 C W Hess
YR 1998
UL http://jnnp.bmj.com/content/65/3/374.abstract
AB The cortical activation pattern of saccades and antisaccades (versus rest) in the frontal lobe was analysed using an echo planar imaging (EPI) technique in 10 healthy subjects. Statistical analysis of activity in the dorsolateral prefrontal cortex disclosed a significantly greater activation during antisaccades in this region than during saccades. On the other hand, activity in the frontal eye fields was not statistically different in both tasks. These results confirm the important role of the dorsolateral prefrontal cortex for the correct performance of antisaccades obtained by studies in humans with isolated lesions of the dorsolateral prefrontal cortex.