PT - JOURNAL ARTICLE AU - T T Warner AU - A H V Schapira TI - The role of the α-synuclein gene mutation in patients with sporadic Parkinson’s disease in the United Kingdom AID - 10.1136/jnnp.65.3.378 DP - 1998 Sep 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 378--379 VI - 65 IP - 3 4099 - http://jnnp.bmj.com/content/65/3/378.short 4100 - http://jnnp.bmj.com/content/65/3/378.full SO - J Neurol Neurosurg Psychiatry1998 Sep 01; 65 AB - Parkinson’s disease is a common neurodegenerative disorder of unknown aetiology. A pathogenic point mutation within the α-synuclein gene has recently been identified in one Italian-American kindred and three families of Greek origin with parkinsonism. DNA from 70 patients with Parkinson’s disease was screened for this G209A mutation. No samples were positive for the mutation, suggesting that it is not relevant for most patients with sporadic idiopathic Parkinson’s disease.