RT Journal Article SR Electronic T1 Crime in Huntington’s disease: a study of registered offences among patients, relatives, and controls JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 467 OP 471 DO 10.1136/jnnp.65.4.467 VO 65 IS 4 A1 Jensen, Per A1 Fenger, Kirsten A1 Bolwig, Tom G A1 Sørensen, Sven Asger YR 1998 UL http://jnnp.bmj.com/content/65/4/467.abstract AB OBJECTIVES Criminal behaviour has been described as a problem in Huntington’s disease, but systematic studies including control groups have been missing. Based on information from Danish registries, rates and types of crime committed by patients with Huntington’s disease, non-affected relatives, and controls were studied. METHODS 99 males and 151 females with Huntington’s disease were compared with 334 non-affected first degree relatives (134 men and 200 women) and to matched control groups as to frequencies and types of registered criminal convictions. Due to specific age criteria, the group of relatives comprised only about 9% carriers of the gene coding for Huntington’s disease. RESULTS In male patients, crime rates were significantly increased compared with first degree relatives (RR=2.8) and controls (RR=2.3). All types of crime occurred more often in male patients; more severe crimes (murder, rape, arson) were not reported. Rates of drunken driving were significantly increased compared with relatives (RR=3.8) and controls (RR=7.1). Crime rates were neither increased in female patients nor in male and female first degree relatives. CONCLUSION The results indicate increased prevalence of criminal behaviour in males carrying the gene for Huntington’s disease. The crimes committed seem to be of relatively minor severity and are probably closely linked to the personality changes often seen as a result of the disease process, although depressive reactions to the disease, with secondary alcohol misuse, may also play a part. Environmental and familial factors shared by patients and non-affected at risk persons seem to be of less aetiological importance.