RT Journal Article
SR Electronic
T1 Regional metabolism: associations with dyscalculia in Alzheimer’s disease
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 913
OP 916
DO 10.1136/jnnp.65.6.913
VO 65
IS 6
A1 Nobutsugu Hirono
A1 Etsuro Mori
A1 Kazunari Ishii
A1 Toru Imamura
A1 Tatsuo Shimomura
A1 Satoshi Tanimukai
A1 Hiroaki Kazui
A1 Mamoru Hashimoto
A1 Hikari Yamashita
A1 Masahiro Sasaki
YR 1998
UL http://jnnp.bmj.com/content/65/6/913.abstract
AB OBJECTIVES The ability to calculate, which is an important aspect of social daily living, is commonly impaired in patients with Alzheimer’s disease even early in the course of the disease. Dyscalculia is often accompanied by focal brain damage, and has been argued to be an independent sign localised around the left temporoparietal region. However, the region most responsible for dyscalculia in Alzheimer’s disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer’s disease was therefore examined. METHODS The calculation ability, In 91 patients with probable Alzheimer’s disease of minimal to moderate severity, was assessed using the arithmetic subtest of the Wechsler adult intelligence scale-revised and the performance correlated with regional cerebral glucose metabolism determined by18F-fluorodeoxyglucose and PET. RESULTS Regional glucose metabolism in the left inferior parietal lobule and in the left inferior temporal gyrus was significantly correlated with the calculation performance irrespective of age, sex, education, and severity of disease. CONCLUSIONS The results suggest that dysfunction of the left inferior parietal lobule and the left inferior temporal gyrus plays an important part in producing dyscalculia in patients with Alzheimer’s disease.