RT Journal Article
SR Electronic
T1 Decreased cerebellar blood flow in postinfectious acute cerebellar ataxia
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 109
OP 112
DO 10.1136/jnnp.67.1.109
VO 67
IS 1
A1 Shinichiro Nagamitsu
A1 Toyojiro Matsuishi
A1 Masatoshi Ishibashi
A1 Yushiro Yamashita
A1 Toshihiro Nishimi
A1 Koutarou Ichikawa
A1 Koichi Yamanishi
A1 Hirohisa Kato
YR 1999
UL http://jnnp.bmj.com/content/67/1/109.abstract
AB OBJECTIVE The aim of the present study was to evaluate the regional cerebral blood flow (rCBF) in patients with postinfectious acute cerebellar ataxia using single photon emission computed tomography (SPECT). METHODS Five children with postinfectious acute cerebellar ataxia and five control subjects were examined. The distribution of rCBF was measured by SPECT imaging after intravenous administration of 123I-IMP (111 MBq). The rCBF ratio—defined as the ratio of rCBF in the region of interest (ROI) to that in the occipital cortex—was calculated for each cortical and subcortical ROI. The mean rCBF ratio of each region was then compared between the ataxic and control subjects. These patients and all control subjects were also evaluated using MRI. RESULTS The rCBF ratio was significantly lower in the cerebellum of the ataxic patients than in the cerebellum of the control subjects (p<0.05). No abnormal cerebellar morphology and no abnormal signal intensities were found on MRI. CONCLUSION 123I-IMP SPECT clearly demonstrated the decreased rCBF in the cerebellum of all patients with postinfectious acute cerebellar ataxia.