TY - JOUR T1 - Alzheimer's disease JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 348 LP - 348 DO - 10.1136/jnnp.68.3.348 VL - 68 IS - 3 AU - J M S PEARCE Y1 - 2000/03/01 UR - http://jnnp.bmj.com/content/68/3/348.abstract N2 - At a psychiatric hospital in Frankfurt, a 51 year old woman (Auguste D), sought help because her family had noticed that she had become uncharacteristically jealous of her husband, and soon became forgetful and tended to get lost. She was fortunate to end up in the hands of Alois Alzheimer, in November 1901.1 When she eventually died in 1906, her brain was sent to Alzheimer, then working in Munich. Alzheimer reported the necropsy of 8 April 1906 to a conference in Tübingen, on 3 and 4 November 1906. An abstract of this report was published in 1907: The Frankfurt archive* has recently been recovered.2 “A woman, 51 years old, showed jealousy towards her husband as the first noticeable sign of the disease. Soon a rapidly increasing loss of memory could be noticed. She could not find her way around in her own apartment. She carried objects back and forth and hid them. At times she would think that someone wanted to kill her and would begin shrieking loudly. In the institution her behaviour bore the stamp of utter perplexity. . . . Periodically she was totally delirious, dragged her bedding around, called her husband and her daughter, and seemed to have auditory hallucinations. . . . “The generalised dementia progressed however. . . . After 4 years of the … ER -