PT  - JOURNAL ARTICLE
AU  - David J Werring
AU  - Ahmed T Toosy
AU  - Christopher A Clark
AU  - Geoffrey JM Parker
AU  - Gareth J Barker
AU  - David H Miller
AU  - Alan J Thompson
TI  - Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke
AID  - 10.1136/jnnp.69.2.269
DP  - 2000 Aug 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 269--272
VI  - 69
IP  - 2
4099  - http://jnnp.bmj.com/content/69/2/269.short
4100  - http://jnnp.bmj.com/content/69/2/269.full
SO  - J Neurol Neurosurg Psychiatry2000 Aug 01; 69
AB  - Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.