RT Journal Article
SR Electronic
T1 Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 269
OP 272
DO 10.1136/jnnp.69.2.269
VO 69
IS 2
A1 David J Werring
A1 Ahmed T Toosy
A1 Christopher A Clark
A1 Geoffrey JM Parker
A1 Gareth J Barker
A1 David H Miller
A1 Alan J Thompson
YR 2000
UL http://jnnp.bmj.com/content/69/2/269.abstract
AB Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.