@article {Watanabe781, author = {H Watanabe and T Ieda and T Katayama and A Takeda and I Aiba and M Doyu and M Hirayama and G Sobue}, title = {Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer{\textquoteright}s disease}, volume = {70}, number = {6}, pages = {781--783}, year = {2001}, doi = {10.1136/jnnp.70.6.781}, publisher = {BMJ Publishing Group Ltd}, abstract = {Cardiac 123I-meta-iodobenzylguanidine (MIBG) uptake was measured in 11 patients with dementia with Lewy bodies (DLB), 10 patients with Alzheimer{\textquoteright}s disease (AD), and 10 age matched control subjects. The severity of cognitive impairment and duration of symptoms in patients with DLB matched that in the patients with AD. The heart/mediastinum (H/M) ratio of MIBG uptake in the patients with AD was indistinguishable from that in the control subjects. However, the H/M ratio in all patients with DLB was significantly lower than that in the patients with AD and control subjects (p\<0.001). These findings indicate that local myocardial sympathetic nerves are affected in DLB and that cardiac 123I-MIBG scintigraphy may provide a means of differentiating DLB from AD.}, issn = {0022-3050}, URL = {https://jnnp.bmj.com/content/70/6/781}, eprint = {https://jnnp.bmj.com/content/70/6/781.full.pdf}, journal = {Journal of Neurology, Neurosurgery \& Psychiatry} }