RT Journal Article
SR Electronic
T1 Primary diffuse leptomeningeal gliomatosis simulating tuberculous meningitis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 120
OP 122
DO 10.1136/jnnp.70.1.120
VO 70
IS 1
A1 J H Rees
A1 N Balakas
A1 A Agathonikou
A1 S F Hain
A1 G Giovanonni
A1 C P Panayiotopoulos
A1 M Luxsuwong
A1 T Revesz
YR 2001
UL http://jnnp.bmj.com/content/70/1/120.abstract
AB Three patients are reported on who presented with communicating hydrocephalus due to presumed tuberculous meningitis. Subsequent clinical deterioration despite antituberculous chemotherapy prompted reassessment with FDG-PET scanning and meningeal biopsy in one case and repeat CSF cytology with special staining in the second. The third patient died and postmortem confirmed a diagnosis of primary diffuse leptomeningeal gliomatosis. In the first two patients, MRI of the entire neuraxis showed no evidence of a primary intraparenchymal tumour. These cases emphasise the need for repeated reassessment in patients with culture negative lymphocytic meningitis. In addition, this is the first report of FDG-PET scanning in leptomeningeal gliomatosis.