RT Journal Article
SR Electronic
T1 Range of cross reactivity of anti-GM1 IgG antibody in Guillain-Barré syndrome
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 123
OP 124
DO 10.1136/jnnp.71.1.123
VO 71
IS 1
A1 M Koga
A1 M Tatsumoto
A1 N Yuki
A1 K Hirata
YR 2001
UL http://jnnp.bmj.com/content/71/1/123.abstract
AB The cross reactivity of anti-GM1 IgG antibody with various gangliosides and asialo-GM1 in serum samples from 27 patients with Guillain-Barré syndrome was investigated. An enzyme linked immunosorbent assay (ELISA) absorption study showed that anti-GM1 IgG antibody cross reacted with asialo-GM1 in 52% of the patients, GM1b in 41%, GD1b in 22%, and GalNAc-GD1a in 19%, and that it did not cross react with GM2, GT1b, or GQ1b. The antibody that cross reacted with GD1b was associated with a high frequency of cranial nerve involvement and negative Campylobacter jejuni serology. Anti-GM1 IgG antibody has a broad range of cross reactivity which may contribute to various clinical variations of Guillain-Barré syndrome.