TY - JOUR T1 - Atypical form of dural graft associated Creutzfeldt-Jakob disease: report of a postmortem case with review of the literature JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 696 LP - 699 DO - 10.1136/jnnp.70.5.696 VL - 70 IS - 5 AU - K Kimura AU - A Nonaka AU - H Tashiro AU - M Yaginuma AU - R Shimokawa AU - R Okeda AU - M Yamada Y1 - 2001/05/01 UR - http://jnnp.bmj.com/content/70/5/696.abstract N2 - A postmortem case of an atypical form of dural graft associated Creutzfeldt-Jakob disease (CJD) is described. A 42 year old man developed progressive spastic paresis 163 months after a cadaveric dura mater graft. He presented with no myoclonus and very late occurrence of periodic synchronous discharges on EEG. The prion protein (PrP) gene was homozygous for methionine at the polymorphic codon 129. Neuropathological examination disclosed plaque-like PrP deposits with atypical distribution of synaptic PrP accumulations in the brain. This patient represents an atypical form of dural graft associated CJD characterised by unusual clinicopathological features. ER -