RT Journal Article
SR Electronic
T1 Atypical form of dural graft associated Creutzfeldt-Jakob disease: report of a postmortem case with review of the literature
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 696
OP 699
DO 10.1136/jnnp.70.5.696
VO 70
IS 5
A1 K Kimura
A1 A Nonaka
A1 H Tashiro
A1 M Yaginuma
A1 R Shimokawa
A1 R Okeda
A1 M Yamada
YR 2001
UL http://jnnp.bmj.com/content/70/5/696.abstract
AB A postmortem case of an atypical form of dural graft associated Creutzfeldt-Jakob disease (CJD) is described. A 42 year old man developed progressive spastic paresis 163 months after a cadaveric dura mater graft. He presented with no myoclonus and very late occurrence of periodic synchronous discharges on EEG. The prion protein (PrP) gene was homozygous for methionine at the polymorphic codon 129. Neuropathological examination disclosed plaque-like PrP deposits with atypical distribution of synaptic PrP accumulations in the brain. This patient represents an atypical form of dural graft associated CJD characterised by unusual clinicopathological features.