PT  - JOURNAL ARTICLE
AU  - A Iranzo
AU  - F Valldeoriola
AU  - J Santamaría
AU  - E Tolosa
AU  - J Rumià
TI  - Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation
AID  - 10.1136/jnnp.72.5.661
DP  - 2002 May 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 661--664
VI  - 72
IP  - 5
4099  - http://jnnp.bmj.com/content/72/5/661.short
4100  - http://jnnp.bmj.com/content/72/5/661.full
SO  - J Neurol Neurosurg Psychiatry2002 May 01; 72
AB  - Objective: To evaluate the sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation (STN-DBS). Methods: Sleep was studied in 11 patients (six women and five men; mean (SD) age 63.6 (7.8) years) who underwent STN-DBS. Subjective sleep evaluation was assessed by clinical sleep interview and the Pittsburgh sleep quality index (PSQI) questionnaire, and sleep architecture by polysomnography with audiovisual recording. Nocturnal mobility was evaluated. Results: Before surgery, eight patients rated their sleep quality as unsatisfactory; seven of these had a marked improvement after surgery, and the PSQI questionnaire showed significantly improved sleep quality. After surgery, polysomnography showed an increase in the longest period of uninterrupted sleep and a decrease in the arousal index. There was an increase in nocturnal mobility after surgery, but no change in REM sleep behaviour disorder. Conclusions: In advanced Parkinson's disease, chronic STN-DBS is associated with subjective improvement in sleep quality, probably through increased nocturnal mobility and reduction of sleep fragmentation.