RT Journal Article
SR Electronic
T1 Association of polymorphisms in the <em>Tau</em> and <em>Saitohin</em> genes with Parkinson’s disease
JF Journal of Neurology, Neurosurgery &amp; Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 478
OP 480
DO 10.1136/jnnp.2003.015750
VO 75
IS 3
A1 C Levecque
A1 A Elbaz
A1 J Clavel
A1 J S Vidal
A1 P Amouyel
A1 A Alpérovitch
A1 C Tzourio
A1 M C Chartier-Harlin
YR 2004
UL http://jnnp.bmj.com/content/75/3/478.abstract
AB Background: The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson’s disease and Tau has been described, Saitohin represents a candidate gene for Parkinson’s disease. Objective: To test these two genes for their association with Parkinson’s disease in a large community based case–control study. Results: Cases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson’s disease onset below 65 years (⩽65 years: OR = 2.52 (1.49 to 4.25); p&lt;0.001) than among those with older onset (&gt;65 years: OR = 1.20 (0.73 to 1.98); p&lt;0.47). Conclusions: The data suggest that there is a functional polymorphism at this locus involved in Parkinson’s disease.