TY - JOUR T1 - The effect of interferon beta-1a on spasticity in primary progressive multiple sclerosis JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 508 LP - 509 DO - 10.1136/jnnp.2003.018598 VL - 75 IS - 3 AU - S M Leary AU - A J Thompson Y1 - 2004/03/01 UR - http://jnnp.bmj.com/content/75/3/508.abstract N2 - It has been suggested that spasticity may be increased in primary progressive multiple sclerosis (PPMS) following treatment with interferon beta.1 In an open study using the Ashworth Scale and a reflex scale, Bramanti et al measured change in spasticity in 19 subjects treated with interferon beta-1b and in 19 untreated subjects. An increase in spasticity during treatment was seen in 68% of the treated participants compared with 11% of the untreated participants. To investigate this phenomenon further, we conducted a retrospective analysis of the spasticity studied in the recently published randomised controlled trial of interferon beta-1a in PPMS.2We … ER -