RT Journal Article
SR Electronic
T1 Mononeuritis multiplex in diabetes mellitus: evidence for underlying immune pathogenesis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 803
OP 806
DO 10.1136/jnnp.74.6.803
VO 74
IS 6
A1 P Kelkar
A1 G J Parry
YR 2003
UL http://jnnp.bmj.com/content/74/6/803.abstract
AB Four patients with type 2 diabetes mellitus developed mononeuritis multiplex subacutely. Sural nerve biopsies showed multifocal axonal loss in all patients, with epineurial perivascular inflammation affecting small calibre vessels in three. Three patients improved with immunotherapy. These observations suggest that mononeuritis multiplex in diabetes may be caused by an immune mediated vasculopathy and that it is pathogenetically akin to the more common and better recognised diabetic amyotrophy.