PT  - JOURNAL ARTICLE
AU  - S Gauggel
AU  - M Rieger
AU  - T-A Feghoff
TI  - Inhibition of ongoing responses in patients with Parkinson’s disease
AID  - 10.1136/jnnp.2003.016469
DP  - 2004 Apr 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 539--544
VI  - 75
IP  - 4
4099  - http://jnnp.bmj.com/content/75/4/539.short
4100  - http://jnnp.bmj.com/content/75/4/539.full
SO  - J Neurol Neurosurg Psychiatry2004 Apr 01; 75
AB  - Objectives: We investigated the involvement of the basal ganglia in inhibiting ongoing responses in patients with Parkinson’s disease (PD). Methods: Thirty two patients with PD and 31 orthopaedic controls performed the stop signal task, which allows an estimation of the time it takes to inhibit an ongoing reaction (stop signal reaction time, SSRT). Results: Patients with PD showed significantly longer SSRTs than the controls. This effect seemed to be independent of global cognitive impairment and severity of PD. Furthermore, in the PD patients, there was no significant relation between general slowing and inhibitory efficiency. Conclusions: Our results provide evidence for involvement of the basal ganglia in the inhibition of ongoing responses.