TY - JOUR T1 - Inhibition of ongoing responses in patients with Parkinson’s disease JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 539 LP - 544 DO - 10.1136/jnnp.2003.016469 VL - 75 IS - 4 AU - S Gauggel AU - M Rieger AU - T-A Feghoff Y1 - 2004/04/01 UR - http://jnnp.bmj.com/content/75/4/539.abstract N2 - Objectives: We investigated the involvement of the basal ganglia in inhibiting ongoing responses in patients with Parkinson’s disease (PD). Methods: Thirty two patients with PD and 31 orthopaedic controls performed the stop signal task, which allows an estimation of the time it takes to inhibit an ongoing reaction (stop signal reaction time, SSRT). Results: Patients with PD showed significantly longer SSRTs than the controls. This effect seemed to be independent of global cognitive impairment and severity of PD. Furthermore, in the PD patients, there was no significant relation between general slowing and inhibitory efficiency. Conclusions: Our results provide evidence for involvement of the basal ganglia in the inhibition of ongoing responses. ER -