PT  - JOURNAL ARTICLE
AU  - S J Pittock
AU  - B G Weinshenker
AU  - E F M Wijdicks
TI  - Mechanical ventilation and tracheostomy in multiple sclerosis
AID  - 10.1136/jnnp.2003.024257
DP  - 2004 Sep 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1331--1333
VI  - 75
IP  - 9
4099  - http://jnnp.bmj.com/content/75/9/1331.short
4100  - http://jnnp.bmj.com/content/75/9/1331.full
SO  - J Neurol Neurosurg Psychiatry2004 Sep 01; 75
AB  - Decisions on ventilatory support (VS) in multiple sclerosis (MS) are complex. All patients with MS requiring mechanical ventilation or tracheostomy since 1969 (22) at Mayo Clinic were reviewed. Seventeen had progressive (PMS; 11 secondary and six primary progressive) and one had relapsing remitting MS (RRMS). Four had neuromyelitis optica (NMO). Of those with PMS, all but two required a wheelchair or were bedbound before VS and survived a median of 22 months; 14 were mechanically ventilated and seven underwent subsequent lifelong tracheostomy; three had tracheostomy only. The indications (usually multiple) for VS in PMS patients were aspiration pneumonia, poor ventilation because of mucous plugging, mechanical failure, and airway control/protection for seizures and coma. The RRMS patient required mechanical ventilation for 10 days, with subsequent short-term tracheostomy during a brainstem exacerbation. Of the four patients with NMO one made a dramatic recovery after plasmapheresis. Compared with PMS, the NMO group had a shorter time from disease onset to VS, a longer duration of ventilation, and the three patients not treated with plasma exchange or steroids did worse. The prognosis for independent ventilation (±tracheostomy) was worst for patients with NMO, except for one patient who received plasma exchange, and better then expected for PMS, despite poor preventilation functional status.