RT Journal Article SR Electronic T1 Repetitive training of compensatory steps: a therapeutic approach for postural instability in Parkinson’s disease JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 1682 OP 1687 DO 10.1136/jnnp.2003.016550 VO 75 IS 12 A1 M Jöbges A1 G Heuschkel A1 C Pretzel A1 C Illhardt A1 C Renner A1 H Hummelsheim YR 2004 UL http://jnnp.bmj.com/content/75/12/1682.abstract AB Background: Postural instability (PI) is a common and serious problem in Parkinson’s disease (PD). Dopaminergic medication is of negligible use and a positive effect of deep brain stimulation on this issue has not been reported. Objective: To develop a method of repetitive training of compensatory steps to enhance protective postural responses by using training strategies based on recent neurophysiological research. Methods: Fourteen patients with PD took part in a multiple baseline design study and were trained for 14 days in an ambulant setting consisting of two daily sessions. Results: After training, the length of compensatory steps increased and the step initiation shortened. In a gait analysis, the cadence and the step length increased, gait velocity improved, and the period of double support shortened. The “mobility” subscore of a quality of life questionnaire (PDQ-39) also improved. All these changes were significant (p < 0.05). These effects were stable for two months without additional training. Conclusion: The repetitive training of compensatory steps is an effective approach in the treatment of PI and should be applied if PI is evident clinically or in a patient’s history.