RT Journal Article SR Electronic T1 Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 643 OP 644 DO 10.1136/jnnp.2003.021865 VO 75 IS 4 A1 M Inglese A1 G L Mancardi A1 E Pagani A1 M A Rocca A1 A Murialdo A1 R Saccardi A1 G Comi A1 M Filippi YR 2004 UL http://jnnp.bmj.com/content/75/4/643.abstract AB To assess whether brain tissue loss occurs after profound and sustained suppression of magnetic resonance imaging (MRI) enhancement, we measured brain volume changes from 10 patients with rapidly evolving secondary progressive multiple sclerosis (MS) treated with autologous haematopoietic stem cell transplantation and followed up for 24 months. An average yearly decrease of brain volume of about 1.9% was observed despite only five enhancing lesions seen on triple dose follow up scans of two patients. This indicates that, in MS, progressive loss of tissue can occur independently of concomitant MRI-visible inflammation.