PT - JOURNAL ARTICLE AU - Y F Tai AU - P Piccini TI - Applications of positron emission tomography (PET) in neurology AID - 10.1136/jnnp.2003.028175 DP - 2004 May 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 669--676 VI - 75 IP - 5 4099 - http://jnnp.bmj.com/content/75/5/669.short 4100 - http://jnnp.bmj.com/content/75/5/669.full SO - J Neurol Neurosurg Psychiatry2004 May 01; 75 AB - Positron emission tomography (PET) is a powerful imaging technique which enables in vivo examination of brain functions. It allows non-invasive quantification of cerebral blood flow, metabolism, and receptor binding. In the past PET has been employed mainly in the research setting due to the relatively high costs and complexity of the support infrastructure, such as cyclotrons, PET scanners, and radiochemistry laboratories. In recent years, because of advancements in technology and proliferation of PET scanners, PET is being increasingly used in clinical neurology to improve our understanding of disease pathogenesis, to aid with diagnosis, and to monitor disease progression and response to treatment. This article aims to provide an overview of the principles of PET and its applications to clinical neurology.