PT  - JOURNAL ARTICLE
AU  - J Haba-Rubio
AU  - L Staner
AU  - C Petiau
AU  - G Erb
AU  - T Schunck
AU  - J P Macher
TI  - Restless legs syndrome and low brain iron levels in patients with haemochromatosis
AID  - 10.1136/jnnp.2003.030536
DP  - 2005 Jul 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1009--1010
VI  - 76
IP  - 7
4099  - http://jnnp.bmj.com/content/76/7/1009.short
4100  - http://jnnp.bmj.com/content/76/7/1009.full
SO  - J Neurol Neurosurg Psychiatry2005 Jul 01; 76
AB  - Regional brain iron levels of two patients with haemochromatosis and severe restless legs syndrome (RLS) were assessed using R2′ magnetic resonance imaging (MRI) sequences in both patients and in nine healthy controls. R2′ relaxation rates in the patients were decreased in the substantia nigra, red nucleus, and pallidum when compared with the controls. These results indicate that local brain iron deficiency may occur in patients with haemochromatosis and suggest a role for brain iron metabolism in the pathophysiology of RLS.