TY - JOUR T1 - Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1039 LP - 1039 DO - 10.1136/jnnp.2004.044438 VL - 76 IS - 7 AU - M W P M Lenders AU - H P J Buschman AU - M D I Vergouwen AU - E N H J Steur AU - P Kölling AU - M Hariz Y1 - 2005/07/01 UR - http://jnnp.bmj.com/content/76/7/1039.1.abstract N2 - Tardive dyskinesia (TD) is a well known side effect of neuroleptic drug treatment, and may coexist with tardive dystonia.1 It can be treated with several drugs, although they rarely lead to a complete removal of symptoms. The main treatment of TD consists of gradual neuroleptic drug dose reduction and where possible complete withdrawal.2 Nevertheless, in 40% of TD cases, symptoms do not disappear within 5 years of drug withdrawal. Wang et al first described a pallidotomy as a treatment modality for TD.3 In severe cases of TD and dystonia, this can lead to significant amelioration of abnormal movements and pronounced improvement in function and quality of life.4 We report a 51 year old, chronically hospitalised man with a 29 year history of schizophrenia. During this period, he was treated successfully for his psychotic symptoms with depot haloperidol and cisordinol. In 1993, he developed TD. Initially it consisted of an involuntary tic (myoclonus-like movements of the orofacial muscles), referred to in the literature as tardive tic.5 Both hands showed dyskinetic and myoclonic movements, the left hand less pronounced than the right, and there was severe … ER -