PT  - JOURNAL ARTICLE
AU  - C M Magariños-Ascone
AU  - I Regidor
AU  - J C Martínez-Castrillo
AU  - M Gómez-Galán
AU  - R Figueiras-Méndez
TI  - Pallidal stimulation relieves myoclonus–dystonia syndrome
AID  - 10.1136/jnnp.2004.039248
DP  - 2005 Jul 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 989--991
VI  - 76
IP  - 7
4099  - http://jnnp.bmj.com/content/76/7/989.short
4100  - http://jnnp.bmj.com/content/76/7/989.full
SO  - J Neurol Neurosurg Psychiatry2005 Jul 01; 76
AB  - A patient with myoclonus–dystonia syndrome was treated by implanting electrodes in the internal segment of the globus pallidus (GPi) and applying deep brain stimulation. Surgery was done in two sessions. The most affected limb was treated first and the other limb one year later. Neuronal recordings showed that most pallidal neurones discharged in bursts at a relatively low firing rate (mean (SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson’s disease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke–Fahn–Marsden and disability rating scales, respectively.