TY - JOUR T1 - Tourette’s syndrome and deep brain stimulation JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 992 LP - 995 DO - 10.1136/jnnp.2004.043273 VL - 76 IS - 7 AU - J L Houeto AU - C Karachi AU - L Mallet AU - B Pillon AU - J Yelnik AU - V Mesnage AU - M L Welter AU - S Navarro AU - A Pelissolo AU - P Damier AU - B Pidoux AU - D Dormont AU - P Cornu AU - Y Agid Y1 - 2005/07/01 UR - http://jnnp.bmj.com/content/76/7/992.abstract N2 - In this prospective double blind randomised “N of 1” study, a patient with a severe form of Tourette’s syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette’s syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder. ER -