RT Journal Article
SR Electronic
T1 Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 953
OP 955
DO 10.1136/jnnp.2005.086116
VO 77
IS 8
A1 Perini, P
A1 Ranzato, F
A1 Calabrese, M
A1 Battistin, L
A1 Gallo, P
YR 2006
UL http://jnnp.bmj.com/content/77/8/953.abstract
AB The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple sclerosis, was found to correlate with the degree of disability (as evaluated by means of the Expanded Disability Status Scale) reached 15 years later (p<0.001). Moreover, a significant inverse correlation was observed between the value of the IgM index and time to the first relapse (p<0.001) and the initiation of the progressive phase of the disease (p = 0.01). The prognostic value of IgM in the CSF is confirmed in previous reports as well as by our study. If these findings are confirmed in patients with multiple sclerosis in a larger series, a helpful biological marker for selecting patients for immunomodulatory treatments will be available to neurologists.