TY - JOUR T1 - Is the frequency of abnormalities on magnetic resonance imaging in isolated optic neuritis related to the prevalence of multiple sclerosis? A global comparison JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1070 LP - 1072 DO - 10.1136/jnnp.2006.090910 VL - 77 IS - 9 AU - J K Swanton AU - K Fernando AU - C M Dalton AU - K A Miszkiel AU - A J Thompson AU - G T Plant AU - D H Miller Y1 - 2006/09/01 UR - http://jnnp.bmj.com/content/77/9/1070.abstract N2 - The link between optic neuritis and multiple sclerosis is well established, as is the increased risk of conversion to multiple sclerosis, with lesions seen at presentation on the magnetic resonance imaging (MRI) scan of the brain. One or more asymptomatic lesions were present in 77% of the optic neuritis cohort from London, UK, a higher proportion than that reported in other large cohorts studied elsewhere, where generally lower prevalence rates for multiple sclerosis are also reported. These observations may support the hypothesis that optic neuritis is more likely to be associated with abnormalities on MRI and to be due to multiple sclerosis in geographical regions where multiple sclerosis is more common. ER -