TY - JOUR T1 - Cholinesterase inhibitor use does not significantly influence the ability of <sup>123</sup>I-FP-CIT imaging to distinguish Alzheimer’s disease from dementia with Lewy bodies JF - Journal of Neurology, Neurosurgery &amp; Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1069 LP - 1071 DO - 10.1136/jnnp.2006.111666 VL - 78 IS - 10 AU - John-Paul Taylor AU - Sean J Colloby AU - Ian G McKeith AU - David J Burn AU - David Williams AU - Jim Patterson AU - John T O’Brien Y1 - 2007/10/01 UR - http://jnnp.bmj.com/content/78/10/1069.abstract N2 - Background: 123I-labelled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-CIT) imaging is a diagnostic tool to help differentiate dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD). However, in animals, cholinesterase inhibitors (ChEi) have been reported to reduce radioligand binding to the striatal dopamine transporter. As ChEi are frequently used in people with dementia, it is important to determine whether their use affects 123I-FP-CIT uptake in the striatum.Objective: To clarify whether chronic ChEi therapy modulates striatal dopamine transporter binding measured by 123I-FP-CIT in patients with AD, DLB and Parkinson’s disease with dementia (PDD).Design: Cross sectional study in 99 patients with AD (nine on ChEi, 25 not on ChEi), DLB (nine on ChEi, 19 not on ChEi) and PDD (six on ChEi, 31 not on ChEi) comparing 123I-FP-CIT striatal binding (caudate, anterior and posterior putamen) in patients receiving compared with those not receiving ChEi, correcting for key clinical variables including diagnosis, age, sex, Mini-Mental State Examination score, severity of parkinsonism and concurrent antidepressant use.Results: As previously described, 123I-FP-CIT striatal uptake was lower in DLB and PDD subjects compared with those with AD. Median duration of ChEi use was 180 days. 123I-FP-CIT uptake was not significantly reduced in subjects receiving ChEi compared those not receiving ChEi (mean percentage reduction: AD 4.3%; DLB 0.7%; PDD 6.1%; p = 0.40). ChEi use did not differentially affect striatal 123FP-CIT uptake between patient groups (p = 0.83).Conclusions: Use of ChEi does not significantly influence the ability of 123I-FP-CIT imaging to distinguish AD from DLB. ER -