TY - JOUR T1 - Reduced perfusion in the anterior cingulate cortex of patients with pure autonomic failure: an <sup>123</sup>I-IMP SPECT study JF - Journal of Neurology, Neurosurgery &amp; Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 1053 LP - 1055 DO - 10.1136/jnnp.2008.152678 VL - 80 IS - 9 AU - S Hirano AU - M Asahina AU - Y Uchida AU - H Shimada AU - R Sakakibara AU - H Shinotoh AU - T Hattori Y1 - 2009/09/01 UR - http://jnnp.bmj.com/content/80/9/1053.abstract N2 - Background: Pure autonomic failure (PAF) is a selective peripheral disorder in which Lewy bodies form within the autonomic ganglia. Patients with this disorder usually have no central lesions; however, chronic autonomic failure may secondarily affect the central nervous system. This study evaluated brain perfusion in patients with PAF by using N-isopropyl-p-123I iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT).Methods: Six patients with PAF (all men; mean (SD) age 68±5 years) who had experienced autonomic symptoms for more than 5 years and six age-matched healthy control subjects (all men; mean (SD) age 67±5 years) were included in this study. The regions of interest (ROI) on spacially normalized 123I-IMP SPECT images were automatically computed for both groups.Results: Perfusion of the dorsal anterior cingulate cortex was decreased in the PAF group compared with the healthy control group (0.93 vs 1.01; p&lt;0.001). In the other brain regions measured, there was no significant difference in regional perfusion between the two groups.Conclusions: The dorsal anterior cingulate cortex is poorly perfused and may be functionally altered in patients with PAF. The reduced perfusion in such individuals may be a secondary change that results from chronic autonomic failure. ER -