PT  - JOURNAL ARTICLE
AU  - Kelly, S
AU  - Connolly, S
AU  - McCarthy, A
AU  - Hutchinson, M
AU  - Murphy, S
AU  - Turbridy, N
TI  - PONM12 Multifocal motor neuropathy due to infliximab
AID  - 10.1136/jnnp.2010.226340.185
DP  - 2010 Nov 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - e63--e63
VI  - 81
IP  - 11
4099  - http://jnnp.bmj.com/content/81/11/e63.3.short
4100  - http://jnnp.bmj.com/content/81/11/e63.3.full
SO  - J Neurol Neurosurg Psychiatry2010 Nov 01; 81
AB  - Infliximab, an anti-TNF-α monoclonal antibody has been reported to cause central demyelination. Neuropathy has occasionally been recorded. We describe multifocal motor neuropathy (MMN) in a 47-year-old man associated with infliximab treatment. A 47-year-old man presented with sub acute onset of left arm weakness and paraesthesiae for 6 weeks. Fine motor tasks were increasingly difficult. He had treatment-refractory. Ulcerative colitis diagnosed in 2003 requiring infliximab for 20 months. Clinically, there was moderate left radial nerve palsy; EMG localised this to the spiral groove. Two weeks later, he developed a left foot drop and a further 2 weeks later, a right C5 root lesion and worsening weakness of ankle dorsiflexion on the left. Investigations for vasculitis were negative. The clinical and repeat EMG features suggested MMN and his symptoms improved over several months with IV immunoglobulin on discontinuation of infliximab. Infliximab may rarely cause MMN.