RT Journal Article
SR Electronic
T1 PONM12 Multifocal motor neuropathy due to infliximab
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP e63
OP e63
DO 10.1136/jnnp.2010.226340.185
VO 81
IS 11
A1 Kelly, S
A1 Connolly, S
A1 McCarthy, A
A1 Hutchinson, M
A1 Murphy, S
A1 Turbridy, N
YR 2010
UL http://jnnp.bmj.com/content/81/11/e63.3.abstract
AB Infliximab, an anti-TNF-α monoclonal antibody has been reported to cause central demyelination. Neuropathy has occasionally been recorded. We describe multifocal motor neuropathy (MMN) in a 47-year-old man associated with infliximab treatment. A 47-year-old man presented with sub acute onset of left arm weakness and paraesthesiae for 6 weeks. Fine motor tasks were increasingly difficult. He had treatment-refractory. Ulcerative colitis diagnosed in 2003 requiring infliximab for 20 months. Clinically, there was moderate left radial nerve palsy; EMG localised this to the spiral groove. Two weeks later, he developed a left foot drop and a further 2 weeks later, a right C5 root lesion and worsening weakness of ankle dorsiflexion on the left. Investigations for vasculitis were negative. The clinical and repeat EMG features suggested MMN and his symptoms improved over several months with IV immunoglobulin on discontinuation of infliximab. Infliximab may rarely cause MMN.