PT  - JOURNAL ARTICLE
AU  - Andrea E Cavanna
AU  - Alessandro Stecco
AU  - Hugh Rickards
AU  - Serena Servo
AU  - Emanuela Terazzi
AU  - Bradley Peterson
AU  - Mary M Robertson
AU  - Alessandro Carriero
AU  - Francesco Monaco
TI  - Corpus callosum abnormalities in Tourette syndrome: an MRI-DTI study of monozygotic twins
AID  - 10.1136/jnnp.2009.173666
DP  - 2010 May 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 533--535
VI  - 81
IP  - 5
4099  - http://jnnp.bmj.com/content/81/5/533.short
4100  - http://jnnp.bmj.com/content/81/5/533.full
SO  - J Neurol Neurosurg Psychiatry2010 May 01; 81
AB  - Background Tourette syndrome (TS) is a chronic neurodevelopmental disorder characterised by the presence of multiple motor and phonic tics. Recent brain imaging investigations with diffusion tensor imaging (DTI) techniques found reduced measures of connectivity in the corpus callosum of children with TS compared with healthy controls, thus raising the hypothesis that the reduced interhemispherical connectivity in TS reflects neural plasticity processes.Methods We assessed corpus callosum white-matter connectivity with fractional anisotropy (FA) index from magnetic resonance-DTI in two monozygotic twins (male sex; age 20) discordant for the diagnosis of TS.Results Both conventional morphological magnetic resonance images and fibre-tracking reconstruction failed to show any difference between the two twins. On the other hand, mean corpus callosum FA values were significantly lower in the affected twin than in the unaffected twin (p<0.01). The differences in FA values were highest in the posterior portions of the corpus callosum, and lowest in the central area.Conclusions Our findings of reduced interhemispherical white-matter connectivity in the affected twin support the hypothesis that plastic remodelling in the corpus callosum possibly represents an adaptation mechanism in TS.