TY - JOUR T1 - Papilloedema and MRI enhancement of the prechiasmal optic nerve at the acute stage of Leber hereditary optic neuropathy JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 578 LP - 580 DO - 10.1136/jnnp.2009.174953 VL - 81 IS - 5 AU - Cédric Lamirel AU - Julien Cassereau AU - Isabelle Cochereau AU - Catherine Vignal-Clermont AU - Olivier Pajot AU - Jean-Yves Tanguy AU - Xavier Zanlonghi AU - Pascal Reynier AU - Patrizia Amati-Bonneau AU - Frédéric Dubas AU - Dominique Bonneau AU - Christophe Verny Y1 - 2010/05/01 UR - http://jnnp.bmj.com/content/81/5/578.abstract N2 - The authors report a case of one patient from a family carrying the homoplasmic Leber hereditary optic neuropathy (LHON) G11778A mitochondrial DNA mutation with papilloedema 9 months prior to the acute stage of LHON and still present at the onset of visual loss. During the vision loss, the MRI demonstrated a T2 hyperintensity and an enhancement of the prechiasmal left optic nerve, suggesting the existence of an inflammatory mechanism. A retrospective review of the chart of two others members of the same family, with bilateral optic disc oedema at onset of the vision loss, suggests that the relationship of papilloedema and acute phase of LHON may not be just a coincidence, at least in this family. The visual loss related to LHON could have been triggered in the setting of the chronic papilloedema, associated with the intracranial hypertension. ER -