PT - JOURNAL ARTICLE AU - Maria Aguirregomozcorta AU - Laura Mancini AU - Thomas M Jenkins AU - Simon J Hickman AU - Olga Ciccarelli AU - Gordon T Plant AU - Alan J Thompson AU - Ahmed T Toosy TI - A longitudinal functional MRI study of non-arteritic anterior ischaemic optic neuropathy patients AID - 10.1136/jnnp.2009.194563 DP - 2011 Aug 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 905--913 VI - 82 IP - 8 4099 - http://jnnp.bmj.com/content/82/8/905.short 4100 - http://jnnp.bmj.com/content/82/8/905.full SO - J Neurol Neurosurg Psychiatry2011 Aug 01; 82 AB - Background Non-arteritic anterior ischaemic optic neuropathy (NA-AION) can cause disabling visual loss and traditionally, visual prognosis has been considered poor, although recent studies have demonstrated improvements in visual acuity in about 30% of patients over time. The aim of the study was to determine whether there was significant cortical reorganisation with functional MRI (fMRI) after acute NA-AION by comparing affected individuals with healthy controls.Methods 9 patients with NA-AION were studied acutely and then after 1, 2, 3 and 6 months. 23 healthy volunteers underwent scanning at least twice. At each time point, patients were assessed clinically and with fMRI. For the fMRI experiments, subjects underwent monocular visual stimulation (wearing goggles with flashing LED displays).Results When stimulating the affected eye, occipital activation was reduced in patients compared with controls. Also, within the NA-AION group, activation in the right Brodmann areas (BA) 44 and 45 was seen during the early phase of the condition. The same areas were activated within the NA-AION group several months later for fellow eye stimulation. When the NA-AION and healthy control groups were formally compared however, these areas (BA 44/45) were not significantly different. NA-AION subjects did show greater activation in visual related areas compared with controls when stimulating the fellow eye. Visual acuity was correlated with more occipital cortex activation when stimulating the affected eye.Conclusions There is cortical re-organisation of the fMRI response in extra-visual areas, seen when both affected and fellow eyes are stimulated after NA-AION.