TY - JOUR T1 - Lupus anticoagulant in patients with subarachnoid haemorrhage JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 89 LP - 90 DO - 10.1136/jnnp.2010.230664 VL - 83 IS - 1 AU - Francis A T M van Lier AU - Rolf T Urbanus AU - Nicolien K de Rooij AU - Gabriel J E Rinkel AU - Catherina C J Frijns Y1 - 2012/01/01 UR - http://jnnp.bmj.com/content/83/1/89.abstract N2 - Background In aneurysmal subarachnoid haemorrhage (SAH), delayed cerebral ischaemia (DCI) is a serious complication that occurs in approximately 30% of patients. Lupus anticoagulant (LAC) is a risk factor for thrombotic events and has been associated with cerebral infarction after SAH.Objective To determine the frequency of LAC in patients with SAH and its association with DCI.Methods Patients with aneurysmal SAH from a prospectively collected database between 1998 and 2009 were included. Presence of LAC was detected with dilute Russell's viper venom time reagents. Investigation of the association with DCI was planned in case of an increased prevalence of LAC compared with the general population.Results Of 511 patients, LAC was detected in only six (1.2%; 95% CI 0.4 to 2.5%). In two of these six patients, DCI was diagnosed.Conclusion No evidence was found that LAC contributes to the development of DCI in patients with aneurysmal SAH. ER -