PT - JOURNAL ARTICLE AU - Mahoney, Colin J AU - Rohrer, Jonathan D AU - Goll, Johanna C AU - Fox, Nick C AU - Rossor, Martin N AU - Warren, Jason D TI - Structural neuroanatomy of tinnitus and hyperacusis in semantic dementia AID - 10.1136/jnnp.2010.235473 DP - 2011 Nov 01 TA - Journal of Neurology, Neurosurgery & Psychiatry PG - 1274--1278 VI - 82 IP - 11 4099 - http://jnnp.bmj.com/content/82/11/1274.short 4100 - http://jnnp.bmj.com/content/82/11/1274.full SO - J Neurol Neurosurg Psychiatry2011 Nov 01; 82 AB - Introduction Tinnitus and hyperacusis are common symptoms of excessive auditory perception in the general population; however, their anatomical substrates and disease associations continue to be defined. Patients with semantic dementia (SemD) frequently report tinnitus and hyperacusis but the significance and basis for these symptoms have not been elucidated.Methods 43 patients with a diagnosis of SemD attending a specialist cognitive disorders clinic were retrospectively studied. 14 patients (32% of the cohort) reported at least moderately severe chronic auditory symptoms: seven had tinnitus and a further seven had hyperacusis, and all had brain MRI while symptomatic. MRI data from SemD patients with and without auditory symptoms were compared using voxel based morphometry in order to identify neuroanatomical associations of tinnitus and hyperacusis.Results Compared with SemD patients with no history of auditory symptoms, patients with tinnitus or hyperacusis had relative preservation of grey matter in the posterior superior temporal lobe and reduced grey matter in the orbitofrontal cortex and medial geniculate nucleus.Conclusions Tinnitus and hyperacusis may be a significant issue in SemD. Neuroanatomical evidence in SemD supports previous work implicating a distributed cortico-subcortical auditory and limbic network in the pathogenesis of these abnormal auditory percepts.