TY - JOUR T1 - Non-motor symptoms in early Parkinson's disease: a 2-year follow-up study on previously untreated patients JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 14 LP - 17 DO - 10.1136/jnnp-2012-303419 VL - 84 IS - 1 AU - Roberto Erro AU - Marina Picillo AU - Carmine Vitale AU - Marianna Amboni AU - Marcello Moccia AU - Katia Longo AU - Autilia Cozzolino AU - Flavio Giordano AU - Anna De Rosa AU - Giuseppe De Michele AU - Maria Teresa Pellecchia AU - Paolo Barone Y1 - 2013/01/01 UR - http://jnnp.bmj.com/content/84/1/14.abstract N2 - Background Non-motor symptoms are very common among patients with Parkinson's disease since the earliest stage, but little is known about their progression and their relationship with dopaminergic replacement therapy. Methods We studied non-motor symptoms before and after 2 years from dopaminergic therapy introduction in ninety-one newly diagnosed previously untreated PD patients. Results At baseline, nearly all patients (97.8%) referred at least one non-motor symptom. At follow-up, only few non-motor symptoms significantly changed. Particularly, depression and concentration became less frequent, while weight change significantly increased after introduction of dopamine agonists. Conclusions We reported for the first time a 2-year prospective study on non-motor symptoms before and after starting therapy in newly diagnosed PD patients. Even if non-motor symptoms are very frequent in early stage, they tend to remain stable during the early phase of disease, being only few non-motor symptoms affected from dopaminergic therapy and, specifically, by the use of dopamine agonists. ER -