RT Journal Article SR Electronic T1 Volume-dependent effect of perihaematomal oedema on outcome for spontaneous intracerebral haemorrhages JF Journal of Neurology, Neurosurgery & Psychiatry JO J Neurol Neurosurg Psychiatry FD BMJ Publishing Group Ltd SP 488 OP 493 DO 10.1136/jnnp-2012-303160 VO 84 IS 5 A1 Geoffrey Appelboom A1 Samuel S Bruce A1 Zachary L Hickman A1 Brad E Zacharia A1 Amanda M Carpenter A1 Kerry A Vaughan A1 Andrew Duren A1 Richard Yeup Hwang A1 Matthew Piazza A1 Kiwon Lee A1 Jan Claassen A1 Stephan Mayer A1 Neeraj Badjatia A1 E Sander Connolly, Jr YR 2013 UL http://jnnp.bmj.com/content/84/5/488.abstract AB Introduction It is still unknown whether subsequent perihaematomal oedema (PHE) formation further increases the odds of an unfavourable outcome. Methods Demographic, clinical, radiographic and outcome data were prospectively collected in a single large academic centre. A multiple logistic regression model was then developed to determine the effect of admission oedema volume on outcome. Results 133 patients were analysed in this study. While there was no significant association between relative PHE volume and discharge outcome (p=0.713), a strong relationship was observed between absolute PHE volume and discharge outcome (p=0.009). In a multivariate model incorporating known predictors of outcome, as well as other factors found to be significant in our univariate analysis, absolute PHE volume remained a significant predictor of poor outcome only in patients with intracerebral haemorrhage (ICH) volumes ≤30 cm3 (OR 1.123, 95% CI 1.021 to 1.273, p=0.034). An increase in absolute PHE volume of 10 cm3 in these patients was found to increase the odds of poor outcome on discharge by a factor of 3.19. Conclusions Our findings suggest that the effect of absolute PHE volume on functional outcome following ICH is dependent on haematoma size, with only patients with smaller haemorrhages exhibiting poorer outcome with worse PHE. Further studies are needed to define the precise role of PHE in driving outcome following ICH.