PT  - JOURNAL ARTICLE
AU  - Jamie Yu Jin Thong
AU  - Saima Hilal
AU  - Yanbo Wang
AU  - Hock Wei Soon
AU  - Yanhong Dong
AU  - Simon Lowes Collinson
AU  - Tuan Ta Anh
AU  - Mohammad Kamran Ikram
AU  - Tien Yin Wong
AU  - Narayanaswamy Venketasubramanian
AU  - Christopher Chen
AU  - Anqi Qiu
TI  - Association of silent lacunar infarct with brain atrophy and cognitive impairment
AID  - 10.1136/jnnp-2013-305310
DP  - 2013 Nov 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1219--1225
VI  - 84
IP  - 11
4099  - http://jnnp.bmj.com/content/84/11/1219.short
4100  - http://jnnp.bmj.com/content/84/11/1219.full
SO  - J Neurol Neurosurg Psychiatry2013 Nov 01; 84
AB  - Objective Silent lacunar infarct (SLI) is associated with cognitive decline and linked to an increased risk of stroke and dementia. We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly. Methods SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition. Results SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction. Conclusions Our findings support a vascular contribution to neurodegeneration and cognitive impairment.