TY - JOUR T1 - MRI in amyotrophic lateral sclerosis: more than a promise JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 710 LP - 710 DO - 10.1136/jnnp-2012-303231 VL - 84 IS - 7 AU - Julian Grosskreutz Y1 - 2013/07/01 UR - http://jnnp.bmj.com/content/84/7/710.abstract N2 - In amyotrophic lateral sclerosis, the deadliest form of motor neuron diseases, physicians observe the spread of non-painful paralysis with intact sensory function often presenting as asymmetric muscle atrophy and brisk or maintained reflexes. Using Awaji criteria to estimate upper and lower motor neuron signs in bulbar, cervical, thoracic and lumbar regions, and the highly sensitive electromyography (EMG), they diagnose amyotrophic lateral sclerosis (ALS) in a majority of the cases. The spread of symptoms is attributed to spinal motor neuron pathology, but experienced ALS neurologists will agree that a slowing of movement, loss of fine motor control and occurrence of mass or mirror … ER -