TY - JOUR T1 - Time to 12-month remission and treatment failure for generalised and unclassified epilepsy JF - Journal of Neurology, Neurosurgery & Psychiatry JO - J Neurol Neurosurg Psychiatry SP - 603 LP - 610 DO - 10.1136/jnnp-2013-306040 VL - 85 IS - 6 AU - Laura J Bonnett AU - Catrin Tudur Smith AU - David Smith AU - Paula R Williamson AU - David Chadwick AU - Anthony G Marson Y1 - 2014/06/01 UR - http://jnnp.bmj.com/content/85/6/603.abstract N2 - Objectives To develop prognostic models for time to 12-month remission and time to treatment failure after initiating antiepileptic drug monotherapy for generalised and unclassified epilepsy. Methods We analysed data from the Standard and New Antiepileptic Drug (arm B) study, a randomised trial that compared initiating treatment with lamotrigine, topiramate and valproate in patients diagnosed with generalised or unclassified epilepsy. Multivariable regression modelling was used to investigate how clinical factors affect the probability of achieving 12-month remission and treatment failure. Results Significant factors in the multivariable model for time to 12-month remission were having a relative with epilepsy, neurological insult, total number of tonic-clonic seizures before randomisation, seizure type and treatment. Significant factors in the multivariable model for time to treatment failure were treatment history (antiepileptic drug treatment prior to randomisation), EEG result, seizure type and treatment. Conclusions The models described within this paper can be used to identify patients most likely to achieve 12-month remission and most likely to have treatment failure, aiding individual patient risk stratification and the design and analysis of future epilepsy trials. ER -