RT Journal Article
SR Electronic
T1 Interhemispheric difference of pallidal local field potential activity in cervical dystonia
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 306
OP 310
DO 10.1136/jnnp-2013-305476
VO 85
IS 3
A1 Jung Ryun Lee
A1 Zelma H T Kiss
YR 2014
UL http://jnnp.bmj.com/content/85/3/306.abstract
AB Background Cervical dystonia (CD) produces involuntary neck muscle contractions that result in abnormal and often asymmetrical postures of the head and neck. Basal ganglia oscillatory activity in the 3–12 Hz band correlating with involuntary muscle activity suggests a role in the pathophysiology of primary dystonia. Despite the asymmetrical postures seen with CD, no comparison of interhemispheric differences of pallidal local field potential (LFP) activity has been reported. Objective The aim of this study was to examine the interhemispheric differences of LFP power in globus pallidus interna (GPi) in CD patients and compare these with their predominant head excursion identified as torticollis, laterocollis and retrocollis. Methods LFPs were recorded from bilateral GPi in 11 patients with CD using microelectrodes during deep brain stimulation surgery. LFP power was measured in right and left GPi separately. The mean percentage of total GPi LFP power in 4–30 Hz frequency band on each brain side was determined and related to their predominant CD symptoms. Results Interhemispheric difference in the mean percentage of LFP power in 4–12 Hz and 13–30 Hz band frequencies was found in patients with torticollis and laterocollis regardless of excursion direction. However, patients with retrocollis did not show interhemispheric difference in LFP activity in any band frequency. Conclusions Interhemispheric differences in synchronisation of pallidal LFP activity in 4–12 Hz and 13–30 Hz bands are related to the CD clinical condition, suggesting that these frequencies are important in the pathophysiology of dystonia.