PT  - JOURNAL ARTICLE
AU  - Claire M Rice
AU  - David Cottrell
AU  - Alastair Wilkins
AU  - Neil J Scolding
TI  - Primary progressive multiple sclerosis: progress and challenges
AID  - 10.1136/jnnp-2012-304140
DP  - 2013 Oct 01
TA  - Journal of Neurology, Neurosurgery & Psychiatry
PG  - 1100--1106
VI  - 84
IP  - 10
4099  - http://jnnp.bmj.com/content/84/10/1100.short
4100  - http://jnnp.bmj.com/content/84/10/1100.full
SO  - J Neurol Neurosurg Psychiatry2013 Oct 01; 84
AB  - Primary progressive multiple sclerosis (MS) has long been recognised as presenting great difficulties to our management of what is increasingly a treatable neurological disease. Here we review some basic and clinical aspects of primary progressive MS, and describe how the disorder in fact offers powerful insights and opportunities for better understanding multiple sclerosis, and from a practical perspective an invaluable clinical substrate for studying and treating progressive disability in MS. Difficult hurdles remain, however, and these too are reviewed.