RT Journal Article
SR Electronic
T1 Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
JF Journal of Neurology, Neurosurgery & Psychiatry
JO J Neurol Neurosurg Psychiatry
FD BMJ Publishing Group Ltd
SP 1065
OP 1075
DO 10.1136/jnnp-2013-307539
VO 85
IS 10
A1 Nadia Magdalinou
A1 Andrew J Lees
A1 Henrik Zetterberg
YR 2014
UL http://jnnp.bmj.com/content/85/10/1065.abstract
AB Parkinsonian diseases comprise a heterogeneous group of neurodegenerative disorders, which show significant clinical and pathological overlap. Accurate diagnosis still largely relies on clinical acumen; pathological diagnosis remains the gold standard. There is an urgent need for biomarkers to diagnose parkinsonian disorders, particularly in the early stages when diagnosis is most difficult. In this review, several of the most promising cerebrospinal fluid candidate markers will be discussed. Their strengths and limitations will be considered together with future developments in the field.